![]() Vasodilator Agents, Cardiovascular Agents, Antihypertensive Agents, Calcium- channel blocking agents, ATC: C0. DB0. 1. H. Kugita et al., U. S. 3,5. 62,2. 57 (1. Diltiazem, a benzothiazepine calcium- channel blocker, is used alone or with an angiotensin- converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Diltiazem is similar to other peripheral vasodilators. Diltiazem inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion- control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. Study Links High-Fat Dairy to Fertility, Low-Fat Dairy to Infertility. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. Do not take more of this medicine and do not take it more often than your doctor ordered. Do not miss any doses. Diltiazem is a calcium channel blocking agents. For the calcium channel blocking agents, the following should be considered: -Tell your doctor if you have ever had any unusual or allergic reaction to amlodipine, bepridil, diltiazem, felodipine, flunarizine, isradipine, nicardipine, nifedipine, nimodipine, or verapamil. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes. ![]() However, studies in animals have shown that large doses of calcium channel blocking agents cause birth defects, prolonged pregnancy, poor bone development in the offspring, and stillbirth. This may increase the chance of side effects during treatment. A lower starting dose may be required. Make sure you tell your doctor if you have any other medical problems, especially. Follow Rxlist link and drugs. I do have same problem also currently doinf sitz bath diltiazem ointment. The first day i put the ointment it helps a lot but aafter a while pain and spasm still on. Advice and warnings for the use of Diltiazem during pregnancy. FDA Pregnancy Category C - Risk cannot be ruled out. Diltiazem, a benzothiazepine calcium-channel blocker, is used alone or with an angiotensin-convertin. Are pregnancy hemorrhoids permanent Metastatic melanoma tumor cells have distinct protein markers called VEG-F.
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